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Anakinra, as a recombinant IL-1 receptor antagonist, can block the biological activity of IL-1 and IL-1, thereby inhibiting the inflammatory cascade (Szabo et al., 2022)

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These locations might represent, respectively, LRP1 in the TfR1-associated recycling pathway en route to the plasma membrane and alone in other intracellular pathways yet to be identified

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For the nonparametric data, the Kruskal-Wallis H-test was used to analyse the significant difference among more than two groups